When polyphenols including Resveratrol, Quercetin, and red wine grape extracts are concentrated into a daily tablet equivalent to over 100 Bottles of red wine (400 – 1000 mg) or more, there is one immediate question, is it safe?
Indeed, scientists who study these nutraceutical supplements have and are continuing to use similar scientific research techniques to those used in the pharmaceutical industry to evaluate their potential health benefits and safety.
In 2002, the National Institute of Environmental Health Sciences commissioned a report entitled, “Trans-resveratrol Review of Toxicological Literature.” A review of more than 200 referenced scientific studies were included, and the report stated that there were no reported adverse effects from Resveratrol on humans.
Animal studies have used the human-equivalent of over 1,000 mg (10 mg/kg of bodyweight) of Resveratrol, and have shown no toxic effects. Massive dosage studies were also performed on animals. “The no observed adverse affect level (NOAEL) was 300 mg/kg/day,” which would be a human dosage of 30,000 mg or 10 – 100 times the maximum concentrations contained in human high-concentration oral nutraceutical dosages.
Human studies also confirm the safety of Resveratrol in highly concentrated forms. Studies including those at Marywood University, University of Leicester (UK) and University of Michigan, etc. all found no significant side effects and no evidence of toxicity.
Personally, members of our company have taken 2,000 mg of Resveratrol and red wine grape extracts for extended periods with no side effects.
Many nutraceutical manufacturing plants are certified by the FDA (US Food and Drug Administration), TGA (Australia’s FDA Certification), NSF, USP (US Pharmacopia), etc. (be sure to check company’s websites for such information).
According to Dr. Joseph Maroon, in his recent book, The Longevity Factor, How Resveratrol and Red Wine Activate Genes for a Longer and Healthier Life (page 198) “Having seen both a pharmaceutical manufacturing plant and a dietary supplement facility I am assured that the manufacturing standards are virtually identical.”
High quality Resveratrol supplements have been on the market since the year 2000, and numerous patients, companies and doctors have reported their safety.
NOTE: Of course, any side-effects experienced as a result of taking Resveratrol, Quercetin, red wine grape extracts, or any other nutraceutical supplements should be reported to the manufacturer, and to your doctor.